INTRAOPERATIVE MITOMYCIN-C, 5-FLUOROURACIL, RETROBULBAR TRIAMCINOLON ACETONIDE, IS IT EQUALLY EFFECTIVE TO DECREASE INTRA OCULAR PRESSURE AFTER TRABECULECTOMY?
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mitomycin-C, 5-fluorouracil, retrobulbar triamcinolone acetonide, surgical success, trabeculectomy
Abstract
Introduction & Objectives
To evaluate the effect of mitomycin-C (MMC), 5-fluorouracil (5-FU), and retrobulbar triamcinolone
acetonide (TA) on the surgical result of trabeculectomy.
Methods
All consecutive trabeculectomies with releasable sutures performed in Sardjito General Hospital
between January 2022 and December 2022 were retrospectively reviewed from medical records.
Patients without any intraoperative metabolite (control group, n=5) were compared to those with
retrobulbar TA (n=5), MMC group (n=19), and 5-FU group (n=11) in terms of surgical success.
Successful surgery results were defined as IOP between 5 - 21 mm Hg without any further
medications or surgical intervention and fewer complications.
Results
40 eyes of 35 patients (15 male, 25 female, mean age 52.4 years) were included in the study. Patient
was observed until post-operation day (POD) 90. There were no significant differences of intraocular
pressure at POD 1, 7, 30, 60, and 90 between control group compared to TCA, MMC, and 5-FU
group. Intraocular pressure pre- and post-operation in each group was significantly different
(p<0.05). The lowest mean intraocular pressure of POD 90 was in 5-FU group (13.64 ± 4.08).
Complication after trabeculectomy in TCA group was 21%, MMC group was 27%, 5-FU group was
10%, and control group was 42%.
Conclusion
MMC, 5-FU, and TCA in this study are equally effective to decrease IOP after trabeculectomy.
Full text article
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Copyright (c) 2023 Yessi Primanda Sari, Retno Ekantini, Tatang Talka Gani, Krisna Dwi Purnomo Jati
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