Corneal Haze after Wavefront Guided PRK at Dr Yap Eye Hospital Yogyakarta: Is There Any Difference Between Low And High Myopia?
Abstract
Background: Wavefront guided Photorefractive Keratectomy (PRK) has regained its popularity. However corneal haze after this procedure often follows. Five to 15% of PRK patients developed corneal haze. The purpose to investigate whether the presence of corneal haze after PRK in low, moderate, and high myopia patients are different and whether these differences influence visual outcome
Method: This was a restrospective cohort study of 589 eyes underwent PRK at Yap Eye Hospital between 2011 and 2012. Visual acuity, refractive status, and corneal haze were examined at 6 times follow up after PRK. Corneal haze was defined as persistent hazy found at three times follow up including the fifth and sixth follow up.
Result: There were 207 males and 77 females with mean age 23,2 years who has clear cornea and 21.5 whose hazy cornea. We found 11.5% of corneal haze in low myopia and 11.2% in high myopia. The proportion of corneal haze in different severity of myopia was not statistically significant (p=0.38). Regardless of the presence of corneal haze, the final visual outcome afterPRK wavefront guided was overall good to excellent (1.00). However the corneal haze condition was resolved ini six months after.
Conclusion: The presence of corneal haze after wavefront guided PRK was similar across different severity of myopia. The presence of corneal hazedid not influence the final visual outcome, which was overall good to excellent.
Â
Keywords: wavefront guided PRK, myopia, corneal haze, visual outcome
Full text article
References
Grosvenor T, “A review and a suggested classification system for myopia on the basis of age-related prevalence and age of 
onsetâ€. Am J Optom Physiol OptJuly 1987(7): 545–54.
Cline, D; Hofstetter HW; Griffin JR.Dictionary of Visual Science. Boston: Butterworth-Heinemann. 1997; 4th ed
Mohan RR, Hutcheon AEK, Choi RC, et al. Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK. Experimental Eye Research 2003; 76: 71-87.
Jester JV, Petroll WM, Cavanagh HD. Corneal stromal wound healing in refractive surgery: the role of myofibroblasts. Progress in Retinal and Eye Research 1999: 18 (3): 311-356.
Moller-Pedersen T, Cavanagh HD, Petroll WM, et al. Stromal wound healing explains refractive instability and haze development after photorefractive keratectomy. Ophthalmology 2000; 107: 1235-1245.
Pietilä J, Mäkinen P, Pajari T, et al. Eight-year follow-up of photorefractive keratectomy for myopia. Journal of Refractive Surgery 2004; 20: 110-115.
Tabbara KF, El-Sheikh HF, Sharara NA, et al. Corneal haze among blue eyes and brown eyes after photorefractive keratectomy. Ophthalmology 1999; 106: 2210-2215.
Stojanovic A, Nitter TA. Correlation between ultraviolet radiation level and the incidence of late onset corneal haze. Journal of Cataract and Refractive Surgery. 2001; 27 (3): 404-410.
American Academy of Ophthalmology. Basic and Clinical Science Course, Section 13: Refractive Surgery, 2009-2010.
Netto MV, Mohan RR, Ambrosio R, et al. Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy. Cornea 2005; 24 (5): 509-522.
Hefetz L, Nemet P. Corneal Hazziness, Br J Ophthalmol 1997;81:637-638