PUPIL CYCLE TIME AND PERIPAPILLARY PERFUSION IN ANGLE CLOSURE GLAUCOMA Oral Presentation - Observational Study - Resident
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Pupil cycle time, Peripapillary flow index, Peripapillary vessel density, Glaucoma
Abstract
Introduction & Objectives
One of important roles in the pathogenesis of glaucoma is vascular condition. To enhance glaucoma
management, the clinical assessment of ocular perfusion is required. The pupillary light reflex's
afferent or efferent pathways may become impaired as a result of pupil cycle time (PCT) elongation.
PCT is a simple objective method to measure the function of optic nerve, including glaucoma. The
purpose of this study is to evaluate the connection between pupil PCT and peripapillary perfusion.
Methods
A cross-sectional study from Kariadi Hospital included 26 eyes with angle closure glaucoma and 26
eyes of healthy patients. Complete ophthalmologic examinations, PCT measurements, and OCT
peripapillary angiography were performed on each patient. Patients with history of drugs use that
can affect pupillary reflexes such as barbiturates, methyldopa, anaesthetics, and antidepressant, and
patients with history of glaucoma attack are excluded. The comparisons between the two groups
were examined, with a p<0.05 indicating statistical significance.
Results
The mean PCT of normal subjects was 943,4ms (882,4ms – 993,4ms) and angle closure glaucoma
subject was 1789,5ms (1060ms – 4600ms). There were statistically significant difference of PCT
value in angle closure glaucoma compared to normal subjects (P<0,05). Peripapillary flow index and
peripapillary vessel density in closed angle glaucomatous eyes were lower than normal eyes
(P<0.05). There is a significant relationship between PCT with peripapillary flow index and
peripapillary vessel density. (P<0,05).
Conclusion
In angle closure glaucoma, prolonged PCT associated with decreased peripapillary perfusion as
shown by decreases in peripapillary flow index and peripapillary vascular density.
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References
Tanna, A. P. et al. Glaucoma. vol. 4 (2020).
Liu, L. et al. Optical coherence tomography angiography of the peripapillary retina in glaucoma. JAMA Ophthalmol. 133, 1045–1052 (2015).
Karti, O. & Karahan, E. The Assessment of Pupil Cycle Time in Patients with Glaucoma. J. Clin. Exp. Ophthalmol. 07, 1–5 (2016).
Yarmohammadi, A. et al. Optical Coherence Tomography Angiography Vessel Density in Healthy , Glaucoma Suspect , and Glaucoma Eyes. doi:10.1167/iovs.15-18944.
Miller, S. D. & Thompson, H. S. Edge-light pupil cycle time. Br. J. Ophthalmol. 62, 495–500 (1978).
Rao, H. L. et al. Optical Coherence Tomography Angiography in Glaucoma. 29, 312–321 (2020).
Milton, J. G. & Longtin, A. Evaluation of pupil constriction and dilation from cycling measurements. Vision Res. 30, 515–525 (1990).
Wybar, C. K. Section of ophthalmology. J. Am. Med. Assoc. XIX, 240–241 (1892).
Kumar, J. R. H., Seelamantula, C. S., Kamath, Y. S. & Jampala, R. Rim-to-Disc Ratio Outperforms Cup-to-Disc Ratio for Glaucoma Prescreening. Sci. Rep. 9, 1–9 (2019).
Chang, D. S., Xu, L., Boland, M. V. & Friedman, D. S. Accuracy of Pupil Assessment for the Detection of Glaucoma. Ophthalmology 120, 2217–2225 (2013).
Why does acute primary angle closure happen? Potential risk factors for acute primary angle closure, Xiulan Zhang, et.al, Zhongshan Ophthalmic Center, Guangzhou, 2016,
Pupil cycle time in primary closed-angle glaucoma, Clark CV, et.al, Journal Canadien D'ophtalmologie, 1986
Van Melkebeke, L., Barbosa-Breda, J., Huygens, M. & Stalmans, I. Optical Coherence Tomography Angiography in Glaucoma: A Review. Ophthalmic Res. 60, 139–151 (2018).
Authors
Copyright (c) 2023 Muhammad Alfin Kamal, Fifin Luthfia Rahmi, Denti Puspasari, Maharani Cahyono
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