The Analysis of Vasculopathy Risk Factors to the Incidence of N-AION
Article Sidebar
Abstract
Background: Nonarteritic Anterior Ischemic Optic Neuropathy (N-AION) is an optic disc oedem caused by ischemic process. The disease often occured at old age population and threatening the vision. Vasculopathy was assumed to accelerate the ischemic process in the incidence of N-AION. The purpose of this study is to analyze the vasculopathy risk factors that play a role to the incidence of N-AION in Kariadi Hospital Semarang.
Methods: This was an analytic observational study with chi square test. Samples were obtained from patient’s medical record who were diagnosed as N-AION in Kariadi Hospital eye’s clinic from January 2012 to June 2014. The data included vasculopathy risk factors consisting of hypertension (blood pressure >140/80 mmHg), diabetic Mellitus (blood sugar >200mg/dl) and dislypidemia, including hypercholesterolemia (>200 mg/dl), hypertriglyceride (>150 mg/dl) and the increase of LDL level (>140 mg/dl). All the data was analysed by SPSS 15.0.
Results: A total of 31 patients of N-AION were reviewed, 20 patients (64,5 %) had risk factors of hypertension and those with diabetic mellitus. Twenty five patients (80.6%) were hypercholesterolemia, 15 patients (48.4%) were hypertriglyceride and 11 patients (25.5%) had increasing LDL level. The statistical testing using chi square test (α = 0,05) resulted only hypercholesterolemia (p=0.001) which had a significant correlation with the incidence of N-AION, meanwhile hypertension (p=0.106), diabetic mellitus (p=0,106) and hypertriglyceride (p=0.857) had no significant correlation.
Conclusion: Statistic analysis of vasculopathy risk factors to the incidence of N-AION indicates that hypercholesterolemia is the most influence risk factor.
Keywords: N-AION, risk factor, vasculopathy
Full text article
References
2. Jianu DC, Jianu SN. Giant cell arterities and arteritic anterior ischemic optic neuropathies. Updates in the Diagnosis and Treatment of Vasculities, 2013:111-28.
3. Hayreh SS, Podhajsky PA. Anterior ischemic optic neuropathies Part 1 in Ophtalmology and Visual Science. University of Iowa Carvier College of Medicine, 2013.
4. Banik R. Nonarteritic anterior ischemic optic neuropathy: an update on demographics, clinical presentation, patophysiology, animal mode, prognosis and treatment. J.Clin Exp Ophtalmol 2013:83-87.
5. Liesegang TJ, Skuta GL, Cantor LB. Basic clinical science course. Neuro- Ophtalmology Section 5. San Fransisco : The Foundation of the American Academy of Ophthalmology ; 2011-2012:12-31,125-129.
6. Kanski JJ. Clinical Ophthalmology A Systemic Approach. 7th Ed. China: Elsevier, 2011:794-99.
7. Hartono. Sari Neuro-Oftalmologi Edisi ke-2. Yogyakarta: Pustaka Rasmedia, 2006:5-10,24-26.
8. RSUP Dr. Kariadi Semarang:Sahabat menuju Sehat. http:// rskariadi.co.id/page/view/4.html.
9. US.Departement of Health and Human Services. Seventh Report of the Joint National Committee on Prevention, Detecton, Evaluation, and Treatment oof High Blood Pressure ( JNC 7). May 2003.
10. American Diabetes Association. Standards of medical care in diabetes—2012. Diabetes Care. 2012;35(Supp 1):S12, table 2.
11. Jellinger PS, Smith DA, Mehta AE, Ganda O, Handelsman Y,et.al. American Association of Clinical Endocrinologists Guidelines for Management of Dyslipidemia and Pevention of Atherosclerosis. Endocrine Practice Vol 18 (Suppl 1) March/April 2012.
12. Younge BR. Anterior ischemic optic neuropathy. Medscape reference. Januari 2014.
13. Riordan-Eva P, Whitcher JP. Ed Susanto D. Oftalmologi umum Vaughan & Asbury Ed.17 Jakarta: EGC. 2008. p.274-277.
14. Golan S, Wasibourd M, Kesler A. Nonarteritic Anterior Ischemic Optic Neuropathy-An Update. J Clinic Experiment Ophtalmol 2011 special issue 3, p 1-10.
15. Palombi K, Renard E, Levy P, Palombi K, Renard E, et al. (2006) Non-arteritic anterior ischaemic optic neuropathy is nearly systematically associated with obstructive sleep apnoea. Br J Ophthalmol 90: 879-882.