DIABETES DURATION AND RETINAL NERVE FIBER LAYER THICKNESS RELATED DEGREE OF DIABETIC RETINOPATHY Oral Presentation - Observational Study - Resident
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Diabetic retinopathy, diabetes mellitus, retinal nerve fiber layer thickness
Abstract
Introduction & Objectives
Diabetic retinopathy is an ocular complication of diabetes mellitus (DM). Several studies have shown
that neurodegenerative changes in the retina occur earlier than microvascular changes.
Measurement of retinal nerve fiber layer thickness can detect neurodegeneration at an early stage.
This study aims to analyze the relationship of diabetes duration and retinal nerve fiber layer
thickness with degree of diabetic retinopathy in type 2 diabetes mellitus patients.
Methods
This research was analytic observational research with cross-sectional design. The sample was type
2 diabetes mellitus patients with diabetic retinopathy who visited the eye clinic at the University of
Sumatera Utara General Hospital. The sample were then analyzed with the Kruskal Wallis test to
find relationship of diabetes duration and retinal nerve fiber layer thickness with degree of diabetic
retinopathy in type 2 diabetes mellitus patients.
Results
The sample of this study were 20 subjects with diabetic retinopathy and 20 subjects without diabetic
retinopathy as the control group. The mean duration of having DM in the group of patients with mild
NPDR was 5.33 years, with moderate NPDR was 9.13 years and with PDR was 15.33 years. Using
the Kruskal Wallis test revealed that there was no significant relationship between degree of
diabetic retinopathy with Avg RNFL (p=0.495), superior RNFL (p=0.385), inferior RNFL (p=0.111),
temporal RNFL (p=0.064), nasal RNFL (p=0.535).
Conclusion
There was a significant difference between diabetes duration with degree of diabetic retinopathy but
no significant between retinal nerve fiber layer thickness with degree of diabetic retinopathy.
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References
Organization WH. World Health Organization Global Report on Diabetes. Geneva World Heal Organ. 2016;
Federation ID. IDF diabetes atlas. ed. Brussels, Belgium Int Diabetes Fed. 2017;
Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010;87(1):4–14.
Yang W, Lu J, Weng J, Jia W, Ji L, Xiao J, et al. Prevalence of diabetes among men and women in China. N Engl J Med. 2010;362(12):1090–101.
Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271–81.
Leasher JL, Bourne RRA, Flaxman SR, Jonas JB, Keeffe J, Naidoo K, et al. Global estimates on the number of people blind or visually impaired by diabetic retinopathy: a metaanalysis from 1990 to 2010. Diabetes Care. 2016;39(9):1643–9.
Yau JWY, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Bek T, et al. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 2012;35(3):556–64.
Wong TY, Sun J, Kawasaki R, Ruamviboonsuk P, Gupta N, Lansingh VC, Maia M, Mathenge W, Moreker S, Muqit MMK, Resnikoff S, Verdaguer J, Zhao P, Ferris F, Aiello LP TH. Updated 2017 ICO Guidelines for Diabetic Eye Care. Int Counc Ophthalmol. 2018;125(10):1–33. 9. Liu L, Wang Y, Liu HX, Gao J. Peripapillary region perfusion and retinal nerve fiber layer thickness abnormalities in diabetic retinopathy assessed by OCT angiography. Transl Vis Sci Technol. 2019;8(4):14.
Simó R, Hernández C. Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives. Trends Endocrinol Metab. 2014;25(1):23–33.
Kern TS, Barber AJ. Retinal ganglion cells in diabetes. J Physiol. 2008;586(18):4401–8.
Vujosevic S, Muraca A, Gatti V, Masoero L, Brambilla M, Cannillo B, et al. Peripapillary microvascular and neural changes in diabetes mellitus: an OCT-angiography study. Invest Ophthalmol Vis Sci. 2018;59(12):5074–81.
Raman R, Ganesan S, Pal SS, Kulothungan V, Sharma T. Prevalence and risk factors for diabetic retinopathy in rural India. Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study III (SN-DREAMS III), report no 2. BMJ Open Diabetes Res Care. 2014;2(1):e000005. https://doi.org/10.1136/bmjdrc-2013-000005
Song P, Yu J, Chan KY, Theodoratou E, Rudan I. Prevalence, risk factors and burden of diabetic retinopathy in China: A systematic review and meta-analysis. J Glob Health. 2018;8(1). https://doi.org/10.7189/jogh.08.010803
Gong X, Wang W, Xiong K, Wang L, Li W, Li Y, et al. Layer and Choroidal Thickness With the Development and Progression of Diabetic Retinopathy. 2022;
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Copyright (c) 2023 Felanda Ahsanu Nadia, Masitha Dewi Sari, Delfi
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